![]() ![]() However, the researchers noted that mice that drank juice had reduced expression of a protein involved in regulating metabolism, so perhaps something in grapefruit changes the way the body makes or stores fat. It’s not exactly clear why grapefruit juice would promote weight loss, especially since the active ingredient – naringin – didn’t have the same effect. But only the juice drinkers saw any benefit on the scale – after 106 days, they weighed 14% less than mice in the other groups. All three “treatments” reduced the mice’s blood sugar compared with drinking sugar water. Then the researchers compared the effects of grapefruit juice with the grapefruit flavonoid naringin and the diabetes drug metformin. After 55 days, the mice who drank grapefruit juice weighed 8% less than the mice who drank water, and they also showed signs of better metabolic function. In a follow-up experiment, the researchers allowed the mice to become obese before they introduced the grapefruit juice. They had lower fasting blood sugar levels, better insulin sensitivity, and lower levels of triglycerides in their livers. ![]() The difference in body weight started to become apparent within 15 days, and the gap was large enough to be statistically significant by day 78, according to the study.Īt the end of the 100 days, the mice who drank juice were in better metabolic health than the ones who drank the same amount of calories in the form of sugar water. (They also ate similar amounts of food.)Īfter eating high-fat chow for 100 days, the mice who drank grapefruit juice weighed 18.4% less than the mice who drank the sweetened water. In the experiments, mice offered grapefruit juice and water drank similar amounts. Second, they gave mice in the control group sugar water made with glucose and saccharin that had the same amount of calories as the sweetened juice. First, they sweetend the pulp-free grapefruit juice (made from California Ruby Red grapefruits) with saccharin. The Berkeley researchers hoped to solve this problem by doing two things. In previous studies of mice that slimmed down when given grapefruit juice instead of water, their weight loss could have been due to the fact that the bitterness caused them to lose their appetites. Mice don’t care for the bitter taste of grapefruit juice, which comes from a flavonoid called naringin. ![]()
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